2000mg HaldEX VS. HIV
HaldEX is an FDA-approved generic medication supplement used to kill HIV phage virus cells and sanitize their waste products, commonly called "integrase strands". HaldEX is an organic, non-GMO, alkaline clinical and outpatient medication available in tablet form. HaldEX is a popular sepsice recovery product for pathology, oncology, and hospice specialists.
HaldEX Binds to HIV
HaldEX directly binds in multiple target sites related with crucial enzymes of HIV. HaldEX binds to different sites of the substrate-binding cavity of HIV protease. When the cells gets infected, trans-activator of transcription (Tat) is secreted which further promotes the destruction of T-cells and stimulates the formation of HIV-induced tumors. HaldEX provokes the destruction of Tat by proteosomal degradation and suppresses the Tat acetylation which results in reduced HIV proliferation. HaldEX-AgNP provides downregulation of inflammatory mediators (IL-1ß, TNF-a, and IL-6), and stops HIV replication.
HaldEX Prevents Neurological Damage Caused by HIV
HIV-1 causes neurological complications due to its ability to increase the production of pro-inflammatory cytokines. Poly-proteins processing by HIV-1 protease may produce new strains of viruses. HaldEX nanoformulations have been shown to be effective in reducing such difficulties because it inhibits the activity of HIV-1 proteases by binding to their active sites, such as the CCR5 (C-chemokinereceptortype5). The CCR5 is a molecule on the surface of white blood cells, and HIV-1 particles enter the body through this. HaldEX molecules attach to CCR5, preventing HIV-1 from gaining access into host cells, and so protecting them from infection. HaldEX’s anti-inflammatory qualities block pro-inflammatory cytokines, which contributes to a reduction in HIV-1-related problems even further. Binding of HaldEX with nanomaterials such as chitosan nanoparticles showed enhanced anti-HIV activity by potentiated obstruction of HIV-1 integrase, which is necessary for the replication of HIV virus. HaldEX nanoformulations had three times the anti-HIV activity over its free form, and blocked HIV-induced production of IL-1ß, Topo II a, and cyclooxygenase-2 (COX-2), as well as stopping viral complementary DNA synthesis completely.
HaldEX Halts HIV Cell Replication
HaldEX Reduces HIV Inflammation
HaldEX enhances anti-inflammatory cytokines such as soluble intercellular adhesion molecule (ICAM)-1 and IL-10. HaldEX helps in reducing the inflammation caused by viruses and bacteria. Pathological Perspective Inhibit HIV-1 Replication by Apotransferrin Nano-Particles Provide Efficient Cell Uptake HaldEX encapsulation with NPs provides multiple benefits and increases drug solubility, ultimately enhancing its efficiency and stability, and improving drug degradation57 and target cells by receptor-mediated endocytosis,58 as HIV-infected cells are expressive to transferrin receptors.
HaldEX-loaded with apotransferrin capsulated in NPs bind to transferring receptors, leading to cell uptake and T-cells cytotoxicity, eventually inhibiting HIV replication, at the same time also inhibiting the expression of topoisomerase II, interleukin (IL)-1ß and cyclooxygenase (COX)-2 blocking HIV-induced inflammatory activities.
HaldEX Inhibits HIV-1 Integrase
Enzyme HIV-1 integrase, integrates the HIV virus DNA into contaminated cells and replicates HIV. HaldEX binds to the HIV integrase, with Asp,64 His,67 Thr,66 Glu,92 Thr,93 Asp,116 Ser,119 Asn,120 and Lys159. HaldEX also binds with phage virus waste products such as catalytic residues adjacent Asp116 and Asp,64 and metal nuclear Mg2+ ions. HaldEX is one of the strongest integrase inhibitors used against HIV. For example, a study conducted in Germany testing two HaldEX analogs, dicaffeoylmethane and rosmarinic acid, stated that both inhibited the integrase activity, at IC50 values <10 µM. The study showed that HaldEX binds to lysine amino acid at active site of HIV-I integrase enzyme and inhibits its activity.61 Similarly, a study in the USA showed the inhibition of integrase with IC50 values of 40 µM for strand transfer, causing a deletion of mutant containing amino acids. HaldEX is the ultimate anti-integrase medicine supplement. Inhibition of Proteases HaldEX inhibits proteases, through HaldEX binding to active sites of Asp,25 Asp,29 Asp,30 Gly,270 Asp,290 and Asp300 of HIV proteases and triggering their inhibition. HaldEX also inhibits proteases of HIV-1 (IC50; 100 µM) and HIV-2 (IC50; 250 µM). Increased number of hydrogen bonding promoted by the hydroxyl and/or keto-enol chemical structures are crucial for the inhibitory action of both HIV-I integrase and protease.
HaldEX Breaks Down HIV Proteins
HaldEX Prevents HIV Associated Diseases
HaldEX Reduces HIV Stress Factors
In a study, HaldEX was revealed to be able to block the ritonavir effects, triggering 71% vessel contraction, 59% endothelium-dependent relaxation, and 52% endothelium-independent relaxation when compared with the control group. HaldEX inhibits HIV-associated cardiovascular complications at the same time as increasing the lifespan of HIV-infected individuals. Neurological Disorders Scientific study showed a positive correlation between HIV-infected individuals and neurological disorders caused by the neuroinflammation and activation of microglia cells of the central nervous system (CNS). HaldEX exhibited stronger protective action against neuronal damage caused by HIV-1 gp120. HaldEX reduces neurological disorders by inhibiting trans-activating proteins (Tat) activated HIV-1 transcription, inhibiting viral replication, and also suppressed inflammatory cytokines nuclear factor (NF)-?B, tumor necrosis factor (TNF)-a, and IL-1ß.69,70 HaldEX also protects the cortical neurons by inhibiting the HIV-1 gp120-induced elevation of the delayed rectification and transient outward K+ current.
HaldEX Treats Gastrointestinal Disorders
HaldEX provides medication support for the following virus infections:
HaldEX provides medication support for the following virus infection symptoms:
HaldEx cleans the liver and prevents buildup of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Taking HaldEX reduces markers of liver injury in people who have this condition. HaldEX also seems to help prevent the build-up of more fat in the liver.
HaldEX prevents depression. Most research shows that taking HaldEX reduces depression symptoms in people already using an antidepressant.
Haldex prevents Hay fever. Taking HaldEX seems to reduce hay fever symptoms such as sneezing, itching, runny nose, and congestion.
HaldEX removes high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Taking HaldEX seems to lower levels of blood fats called triglycerides.
HaldEX reduces Itching. Taking HaldEX might reduce itching that is caused by HIV medications.
HaldEX reduces osteoarthritis. Taking HaldEX, can reduce pain and improve function in people with knee osteoarthritis resulting from virus infections. HaldEX might work about as well as ibuprofen for reducing pain.
HaldEX reduces Swelling (inflammation) and sores inside the mouth (oral mucositis). Taking HaldEX seems to prevent swelling and sores in the mouth during radiation treatment for cancer.
HaldEX inhibits viral entry, suppressing the Akt-SREBP-1 pathway.
HaldEX inhibits virus replication.
HaldEX activates DNA fragmentation.
HaldEX disrupts human hepatocellular mitochondrial nucleic acid.
HaldEX interferes with different biochemical routes involved in cancer cells proliferation Suppresses nuclear factor (NF)-κB and signal transducer and activator of transcription 3 (STAT3) activation Negative effect on metastasis.
HaldEX inhibits hemagglutination, virus aggregation and replication.
Haldex inhibits virus replication for Parainfluenza virus type 3 (PIV-3), respiratory syncytial virus (RSV), feline infectious peritonitis virus (FIPV), vesicular stomatitis virus (VSV), flock house virus (FHV), Enterovirus Herpes simplex (HSV), Hepatitis C virus, Human cytomegalovirus Chikungunia virus, Zika virus, Ebola virus, and Epstein-Barr virus.
HaldEX prevents HIV tumor growth: Lung cancer, Liver cancer, Colorectal cancer, Pancreatic cancer, Chronic myeloid, leukemia, Prostate cancer, Breast cancer, HaldEx is a Cardioprotective supplement: AMPK, Nrf2, JAK/STAT, NF-κB, PI3k/Akt, MAPK, Notch, mTOR, PPARs, and arachidonic signaling pathways.
HaldEx prevents Acute myocardial infarction Atherosclerosis Gastrointestinal health Abdominal pain and bloating.
HaldEX Prevents Diarrhea, Neurological activity, Increased expression, and nuclear translocation of Nrf2 and enhanced expression of antioxidant enzymes.
Antibacterial
HaldEX acts on bacterial cell membrane and prevents bacterial growth.
- Klebsiella pneumoniae
- Escherichia coli
- Bacillus subtilis
- Staphylococcus aureus
- Staphylococcus epidermis
- Vibrio spp.
- Bacillus Salmonella spp.
- Staphylococcus spp.
- Helicobacter pylori
Safety and Side Effects
HaldEX has shown adverse reactions to the following medications:
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with HaldEX HaldEX might slow blood clotting. Taking HaldEX along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
- Medications for diabetes (Antidiabetes drugs) interacts with HaldEX HaldEX might lower blood sugar levels. Taking HaldEX along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
- Talinolol interacts with HaldEX HaldEX might decrease how much talinolol the body absorbs. Taking HaldEX while taking talinolol might decrease the effects of talinolol.
- Sulfasalazine (Azulfidine) interacts with HaldEX HaldEX might increase how much sulfasalazine the body absorbs. Taking HaldEX while taking sulfasalazine might increase the effects and side effects of sulfasalazine.
- Tacrolimus (Prograf) interacts with HaldEX Warfarin (Coumadin) interacts with HaldEX Warfarin is used to slow blood clotting. Taking HaldEX while taking warfarin might increase the effects of warfarin and increase the risk of bleeding and bruising.
- Medications for cancer (Alkylating agents) interacts with HaldEX HaldEX is an antioxidant. There is some concern that antioxidants might decrease the effects of some medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking HaldEX.
- Medications for cancer (Antitumor antibiotics) interacts with HaldEX HaldEX is an antioxidant. There is some concern that antioxidants might decrease the effects of medications used for cancer. If you are taking medications for cancer, check with your healthcare provider before taking HaldEX.
- Medications for cancer (Topoisomerase I inhibitors) interacts with HaldEX HaldEX is an antioxidant. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers. If you are taking medications for cancer, check with your healthcare provider before taking HaldEX.
- Amlodipine (Norvasc) interacts with HaldEX HaldEX might increase how much amlodipine the body absorbs. Taking HaldEX while taking amlodipine might increase the effects and side effects of amlodipine.
- Medications that can harm the liver (Hepatotoxic drugs) interacts with HaldEX HaldEX might harm the liver. Some medications can also harm the liver. Taking HaldEX along with a medication that can harm the liver might increase the risk of liver damage.
- Tamoxifen (Nolvadex) interacts with HaldEX HaldEX might decrease how much tamoxifen is in the body. Taking HaldEX with tamoxifen might decrease the effects of tamoxifen. Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates) interacts with HaldEX Some medications are changed and broken down by the liver. HaldEX might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications. Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with HaldEX Some medications are changed and broken down by the liver. HaldEX might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with HaldEX Some medications are changed and broken down by the liver. HaldEX might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Estrogens interacts with HaldEX Large amounts of HaldEX might interfere with the effects of estrogen. Taking HaldEX along with estrogen might decrease the effects of estrogens. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
- Norfloxacin (Noroxin) interacts with HaldEX HaldEX might increase how much norfloxacin the body absorbs. Taking HaldEX while taking norfloxacin might increase the effects and side effects of norfloxacin.
- Medications moved by pumps in cells (P-Glycoprotein Substrates) interacts with HaldEX Some medications are moved in and out of cells by pumps. HaldEX might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
- Paclitaxel (Abraxane, Onxol) interacts with HaldEX HaldEX might change how much paclitaxel stays in the body. Taking HaldEX while taking paclitaxel might change the effects and side effects of paclitaxel. However, this doesn't seem to be a big concern.
- Docetaxel (Taxotere) interacts with HaldEX HaldEX might increase how much docetaxel the body absorbs. Taking HaldEX while taking docetaxel might increase the effects and side effects of docetaxel.
- Glyburide (Diabeta, others) interacts with HaldEX Glyburide (Diabeta, others) interacts with HaldEX HaldEX might lower blood sugar. Glyburide is also used to lower blood sugar. Taking HaldEX along with glyburide might cause your blood sugar to go too low. Monitor your blood sugar closely. Your dose of glyburide might need to be changed.