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Diagnosed with stage 4 kidney cancer, a woman is disease-free after immunotherapy - Fred Hutchinson Cancer Center

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Written by: Dr. Correo “Cory” Andrew Hofstad J.S.D MPHJD MSPH JD Ph.D. M.D. D.O. MBACOGS MDiv
Parent Category: Medical News
Category: Oncology
Diagnosed with stage <div readability="35"> <h3>Exploring an approach to reduced-frequency dosing</h3> <p>The decision? A unique Fred Hutch-developed approach that called for a lower-intensity treatment every three months instead of every four weeks. <a target="_blank" href="http://www.fredhutch.org/en/provider-directory/lisa-tachiki.html" target="_self">Lisa Tachiki, MD</a>, and <a target="_blank" href="http://www.fredhutch.org/en/provider-directory/shailender-bhatia.html" target="_self">Shailender Bhatia, MD</a>, recently <a target="_blank" href="https://link.springer.com/epdf/10.1007/s00262-023-03539-8?sharing_token=PY2xgBEhsK1e8iJ2lkA-Rfe4RwlQNchNByi7wbcMAY781eHfp_TZC3GtOv8V7y_xwxCLVu1ATrM631L14P0-PJ29i-_mTDU6B7XHuyPyV_SPD6GWMqyg2u2Kre_29QhAWEu7-KG2TwUB89fAVtMAGZIPD4JCn1jWINLigSUx_U8=" target="_blank">published a study</a> about the approach and are engaged in ongoing research to show that reduced-frequency dosing, an approach to “step-down dosing,” may be a good option.</p> <p>Reduced-frequency dosing has been used with a number of skin cancer patients at Fred Hutch, but the same principles apply to kidney cancer patients.  </p> <p>“This approach is unique to our center,” Hall said. “In some cancers, there is a growing concern there could be late progression years later, so the thinking is that continued treatment may reduce that chance.”</p> <p><a target="_blank" href="http://www.fredhutch.org/en/news/center-news/2023/12/bhatia-tachiki-reduced-frequency-immune-checkpoint-inhibitor.html" target="_self">Spacing out dosing</a> is not a standard way to deliver immunotherapy, but it may become more accepted for those patients who have had good responses to standard dosing.</p> <p>“We have data to show that if we increase the time between doses after patients like Lacey have responded well to standard doses of immunotherapy, patients may continue to do well without compromising the efficacy of immunotherapy,” Tachiki said. “There is biological evidence that step-down dosing would be relevant for any cancer that responds to immunotherapy.”</p> <p>One compelling reason to opt for step-down dosing is that patients can be extremely reluctant to stop a drug that’s working well to keep them alive. Some research has found that stopping immunotherapy after a year instead of two years is not as effective at controlling lung cancer. </p> <p>“Reduced-frequency dosing provides an option for patients to continue immunotherapy, rather than stop entirely, while still using less drug and saving cost and time of drug infusions,” said Tachiki. “It's a middle-path approach.” </p> <p>The ideal duration for reduced-frequency dosing is unknown, but patients such as Lacey are helping physician-scientists crack the code by participating in research.</p> <p>“My life has changed,” said Lacey, who runs <a target="_blank" href="https://museumwithoutwalls.org/" target="_blank">Museum Without Walls</a>, a nonprofit she started two decades ago that develops oral history programs around themes of racism and intolerance. "I was really depressed. I was grieving. I missed my dad. But the moment I got this diagnosis, I had a clear epiphany that no, I didn’t want to die. I see life differently, and my appreciation for every moment, even when I'm exhausted, is different, and I owe that to my best friends and Fred Hutch.”</p></div><span class="obgb_original_source"> <p class="obgb_original_text">Content Original Link:</p> <p class="obgb_original_url"><a href="https://www.fredhutch.org/en/news/center-news/2024/03/diagnosed-with-stage-4-kidney-cancer-woman-is-disease-free-after-immunotherapy.html" target="_blank">https://www.fredhutch.org/en/news/center-news/2024/03/diagnosed-with-stage-4-kidney-cancer-woman-is-disease-free-after-immunotherapy.html</a></p> </span> </div> <nav class="pagenavigation" aria-label="Page Navigation"> <span class="pagination ms-0"> <a class="btn btn-sm btn-secondary previous" href="/oncology/coding-for-cancer-fred-hutchinson-cancer-center" rel="prev"> <span class="visually-hidden"> Previous article: Coding for Cancer - Fred Hutchinson Cancer Center </span> <span class="icon-chevron-left" aria-hidden="true"></span> <span aria-hidden="true">Prev</span> </a> <a class="btn btn-sm btn-secondary next" href="/oncology/amenities-fred-hutchinson-cancer-center" rel="next"> <span class="visually-hidden"> Next article: Amenities - Fred Hutchinson Cancer Center </span> <span aria-hidden="true">Next</span> <span class="icon-chevron-right" aria-hidden="true"></span> </a> </span> </nav> </div></div></div></div></div> </div> </div> </div> <div class="g-grid"> <div class="g-block size-100 largemarginall"> <div class="g-content"> <div class="mainbottom-a moduletable "> <div id="module-cta-161-particle" class="g-particle"><div class="g-cta"> <div class="g-cta-patterns-left"> <svg viewbox="0 0 1199 241" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M116 141L159.301 166V216L116 241L72.6987 216V166L116 141Z" class="base-pattern-1"/> <path d="M69.5 125L84.6554 133.75V151.25L69.5 160L54.3446 151.25V133.75L69.5 125Z" class="base-pattern-2"/> <path d="M35 149L65.3109 166.5V201.5L35 219L4.68911 201.5V166.5L35 149Z" class="base-pattern-3"/> </svg> </div> <div class="g-cta-patterns-right"> <svg viewbox="0 0 1199 241" fill="none" xmlns="http://www.w3.org/2000/svg"> <path d="M1083 0L1126.3 25V75L1083 100L1039.7 75V25L1083 0Z" class="base-pattern-3"/> <path d="M808 8L838.311 25.5V60.5L808 78L777.689 60.5V25.5L808 8Z" class="base-pattern-1"/> <path d="M707 138L737.311 155.5V190.5L707 208L676.689 190.5V155.5L707 138Z" class="base-pattern-2"/> <path d="M1164 8L1194.31 25.5V60.5L1164 78L1133.69 60.5V25.5L1164 8Z" class="base-pattern-2"/> <path d="M1181.5 75L1196.66 83.75V101.25L1181.5 110L1166.34 101.25V83.75L1181.5 75Z" class="base-pattern-3"/> </svg> </div> <div class="g-cta-left"> <h2>Access Non-GMO, antigen-free, FDA-approved antiviral medication formulas used in Moderna's Spikevax.</h2> <p>VirusTC is a retail provider of concentrated FDA-approved antiviral medication formulas. 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